Changes of Cell Biochemical States Are Revealed in Protein Homomeric Complex Dynamics

We report here a simple and global strategy to map out gene functions and target pathways of drugs, toxins, or other small molecules based on “homomer dynamics” protein-fragment complementation assays (hdPCA). hdPCA measures changes in self-association (homomerization) of over 3,500 yeast proteins i...

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Detalles Bibliográficos
Autores principales: Stynen, Bram, Abd-Rabbo, Diala, Kowarzyk, Jacqueline, Miller-Fleming, Leonor, Aulakh, Simran Kaur, Garneau, Philippe, Ralser, Markus, Michnick, Stephen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242466/
https://www.ncbi.nlm.nih.gov/pubmed/30454649
http://dx.doi.org/10.1016/j.cell.2018.09.050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242466/
https://www.ncbi.nlm.nih.gov/pubmed/30454649
http://dx.doi.org/10.1016/j.cell.2018.09.050

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