Cargando…

Changes of Cell Biochemical States Are Revealed in Protein Homomeric Complex Dynamics

We report here a simple and global strategy to map out gene functions and target pathways of drugs, toxins, or other small molecules based on “homomer dynamics” protein-fragment complementation assays (hdPCA). hdPCA measures changes in self-association (homomerization) of over 3,500 yeast proteins i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stynen, Bram, Abd-Rabbo, Diala, Kowarzyk, Jacqueline, Miller-Fleming, Leonor, Aulakh, Simran Kaur, Garneau, Philippe, Ralser, Markus, Michnick, Stephen W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242466/ https://www.ncbi.nlm.nih.gov/pubmed/30454649 http://dx.doi.org/10.1016/j.cell.2018.09.050

Ejemplares similares

Delineating functional principles of the bow tie structure of a kinase-phosphatase network in the budding yeast
por: Abd-Rabbo, Diala, et al.
Publicado: (2017)

Evolution of protein complexes by duplication of homomeric interactions
por: Pereira-Leal, Jose B, et al.
Publicado: (2007)

Functional determinants of protein assembly into homomeric complexes
por: Bergendahl, L. Therese, et al.
Publicado: (2017)

Functional and genetic determinants of mutation rate variability in regulatory elements of cancer genomes
por: Lee, Christian A., et al.
Publicado: (2021)

Global analysis of protein homomerization in Saccharomyces cerevisiae
por: Kim, Yeonsoo, et al.
Publicado: (2019)

Mover Is a Homomeric Phospho-Protein Present on Synaptic Vesicles
por: Ahmed, Saheeb, et al.
Publicado: (2013)

Ligand Binding Site Structure Shapes Folding, Assembly and Degradation of Homomeric Protein Complexes
por: Abrusán, György, et al.
Publicado: (2019)

Inter-Subunit Coordination in a Homomeric Ring-ATPase
por: Moffitt, Jeffrey R., et al.
Publicado: (2009)

The structural arrangement at intersubunit interfaces in homomeric kainate receptors
por: Litwin, Douglas B., et al.
Publicado: (2019)

Maintaining and breaking symmetry in homomeric coiled-coil assemblies
por: Rhys, Guto G., et al.
Publicado: (2018)

Metabolic heterogeneity and cross-feeding within isogenic yeast populations captured by DILAC
por: Kamrad, Stephan, et al.
Publicado: (2023)

Determining the interaction status and evolutionary fate of duplicated homomeric proteins
por: Mallik, Saurav, et al.
Publicado: (2020)

The Effects of Terminal Tagging on Homomeric Interactions of the Sigma 1 Receptor
por: Yano, Hideaki, et al.
Publicado: (2019)

The intracellular domain of homomeric glycine receptors modulates agonist efficacy
por: Ivica, Josip, et al.
Publicado: (2021)

The specificity of homomeric clustering of CD81 is mediated by its δ‐loop
por: Homsi, Yahya, et al.
Publicado: (2017)

Allosteric Recognition of Homomeric and Heteromeric Pairs of Monosaccharides by a Foldamer Capsule
por: Mateus, Pedro, et al.
Publicado: (2020)

Spontaneously established syntrophic yeast communities improve bioproduction
por: Aulakh, Simran Kaur, et al.
Publicado: (2023)

Assembly and Trafficking of Homomeric and Heteromeric Kainate Receptors with Impaired Ligand Binding Sites
por: Scholefield, Caroline L., et al.
Publicado: (2018)

A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family
por: Ranjan, Rajnish, et al.
Publicado: (2019)

A novel small-molecule selective activator of homomeric GIRK4 channels
por: Cui, Meng, et al.
Publicado: (2022)

Influence of hemodynamics and intra-operative hydration on biochemical outcome of renal transplant recipients
por: Aulakh, Navpreet Kaur, et al.
Publicado: (2015)

Genome-wide SWAp-tag yeast libraries for proteome exploration
por: Weill, Uri, et al.
Publicado: (2018)

General rules for the arrangements and gating motions of pore-lining helices in homomeric ion channels
por: Dai, Jian, et al.
Publicado: (2014)

Homomeric GluA2(R) AMPA receptors can conduct when desensitized
por: Coombs, Ian D., et al.
Publicado: (2019)

Structural Arrangement Produced by Concanavalin A Binding to Homomeric GluK2 Receptors
por: Gonzalez, Cuauhtemoc U., et al.
Publicado: (2021)

Chlamydia trachomatis Polymorphic Membrane Proteins (Pmps) Form Functional Homomeric and Heteromeric Oligomers
por: Favaroni, Alison, et al.
Publicado: (2021)

Alkaloid ligands enable function of homomeric human α10 nicotinic acetylcholine receptors
por: Hone, Arik J., et al.
Publicado: (2022)

Teneurin4 dimer structures reveal a calcium‐stabilized compact conformation supporting homomeric trans‐interactions
por: Meijer, Dimphna H, et al.
Publicado: (2022)

A CUG codon adapted two-hybrid system for the pathogenic fungus Candida albicans
por: Stynen, Bram, et al.
Publicado: (2010)

Structural basis for Ccd1 auto-inhibition in the Wnt pathway through homomerization of the DIX domain
por: Terawaki, Shin-ichi, et al.
Publicado: (2017)

The Calmodulin Binding Region of the Synaptic Vesicle Protein Mover Is Required for Homomeric Interaction and Presynaptic Targeting
por: Akula, Asha Kiran, et al.
Publicado: (2019)

Subcellular Localization of Homomeric TASK3 Channels and Its Presumed Functional Significances in Trigeminal Motoneurons
por: Saito, Mitsuru, et al.
Publicado: (2022)

Publisher Correction: General rules for the arrangements and gating motions of pore-lining helices in homomeric ion channels
por: Dai, Jian, et al.
Publicado: (2018)

Cell surface expression of homomeric GABA(A) receptors depends on single residues in subunit transmembrane domains
por: Hannan, Saad, et al.
Publicado: (2018)

p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
por: Ge, Yuan, et al.
Publicado: (2019)

Homomeric and Heteromeric α7 Nicotinic Acetylcholine Receptors in Health and Some Central Nervous System Diseases
por: Borroni, Virginia, et al.
Publicado: (2021)

Integrative pathway enrichment analysis of multivariate omics data
por: Paczkowska, Marta, et al.
Publicado: (2020)

Author Correction: Integrative pathway enrichment analysis of multivariate omics data
por: Paczkowska, Marta, et al.
Publicado: (2022)

Openings of the Rat Recombinant α1 Homomeric Glycine Receptor as a Function of the Number of Agonist Molecules Bound
por: Beato, Marco, et al.
Publicado: (2002)

A Benchmark for Homomeric Enzyme Active Site Structure Prediction Highlights the Importance of Accurate Modeling of Protein Symmetry
por: Contreras, Stephanie C., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_oat81iv3hrqtelpn9ba526lqt8