Critical Role of the UBL Domain in Stimulating the E3 Ubiquitin Ligase Activity of UHRF1 toward Chromatin

The RING E3 ubiquitin ligase UHRF1 controls DNA methylation through its ability to target the maintenance DNA methyltransferase DNMT1 to newly replicated chromatin. DNMT1 recruitment relies on ubiquitylation of histone H3 by UHRF1; however, how UHRF1 deposits ubiquitin onto the histone is unknown. H...

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Detalles Bibliográficos
Autores principales: Foster, Benjamin M., Stolz, Paul, Mulholland, Christopher B., Montoya, Alex, Kramer, Holger, Bultmann, Sebastian, Bartke, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242706/
https://www.ncbi.nlm.nih.gov/pubmed/30392929
http://dx.doi.org/10.1016/j.molcel.2018.09.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242706/
https://www.ncbi.nlm.nih.gov/pubmed/30392929
http://dx.doi.org/10.1016/j.molcel.2018.09.028

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