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Polymer Simulations of Heteromorphic Chromatin Predict the 3D Folding of Complex Genomic Loci

Chromatin folded into 3D macromolecular structures is often analyzed by chromosome conformation capture (3C) and fluorescence in situ hybridization (FISH) techniques, but these frequently provide contradictory results. Chromatin can be modeled as a simple polymer composed of a connected chain of uni...

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Detalles Bibliográficos
Autores principales: Buckle, Adam, Brackley, Chris A., Boyle, Shelagh, Marenduzzo, Davide, Gilbert, Nick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242782/
https://www.ncbi.nlm.nih.gov/pubmed/30344096
http://dx.doi.org/10.1016/j.molcel.2018.09.016