Sumoylation of RORγt regulates T(H)17 differentiation and thymocyte development

RORγt controls the differentiation of T(H)17 cells, which are mediators of autoimmune conditions such as experimental autoimmune encephalomyelitis (EAE). RORγt also regulates thymocyte development and lymph node genesis. Here we show that the function of RORγt is regulated by its sumoylation. Loss o...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Zhiheng, Zhang, Jing, Huang, Zhaofeng, Du, Qian, Li, Ning, Zhang, Qiang, Chen, Yuan, Sun, Zuoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242824/
https://www.ncbi.nlm.nih.gov/pubmed/30451821
http://dx.doi.org/10.1038/s41467-018-07203-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242824/
https://www.ncbi.nlm.nih.gov/pubmed/30451821
http://dx.doi.org/10.1038/s41467-018-07203-z

Ejemplares similares