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Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions

The precise interplay between the mRNA codon and the tRNA anticodon is crucial for ensuring efficient and accurate translation by the ribosome. The insertion of RNA nucleobase derivatives in the mRNA allowed us to modulate the stability of the codon-anticodon interaction in the decoding site of bact...

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Detalles Bibliográficos
Autores principales: Hoernes, Thomas Philipp, Faserl, Klaus, Juen, Michael Andreas, Kremser, Johannes, Gasser, Catherina, Fuchs, Elisabeth, Shi, Xinying, Siewert, Aaron, Lindner, Herbert, Kreutz, Christoph, Micura, Ronald, Joseph, Simpson, Höbartner, Claudia, Westhof, Eric, Hüttenhofer, Alexander, Erlacher, Matthias David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242847/
https://www.ncbi.nlm.nih.gov/pubmed/30451861
http://dx.doi.org/10.1038/s41467-018-07321-8