Cargando…
Characterization of a new N-terminally acetylated extra-mitochondrial isoform of frataxin in human erythrocytes
Frataxin is a highly conserved protein encoded by the frataxin (FXN) gene. The full-length 210-amino acid form of protein frataxin (1–210; isoform A) expressed in the cytosol of cells rapidly translocates to the mitochondria, where it is converted to the mature form (81–210) by mitochondrial process...
Autores principales: | Guo, Lili, Wang, Qingqing, Weng, Liwei, Hauser, Lauren A., Strawser, Cassandra J., Mesaros, Clementina, Lynch, David R., Blair, Ian A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242848/ https://www.ncbi.nlm.nih.gov/pubmed/30451920 http://dx.doi.org/10.1038/s41598-018-35346-y |
Ejemplares similares
-
Simultaneous Quantification of Mitochondrial Mature Frataxin and Extra-Mitochondrial Frataxin Isoform E in Friedreich’s Ataxia Blood
por: Wang, Qingqing, et al.
Publicado: (2022) -
Extra-mitochondrial mouse frataxin and its implications for mouse models of Friedreich’s ataxia
por: Weng, Liwei, et al.
Publicado: (2020) -
Evaluation of antibodies for western blot analysis of frataxin protein isoforms
por: Weng, Liwei, et al.
Publicado: (2019) -
Low apolipoprotein A-I levels in Friedreich’s ataxia and in frataxin-deficient cells: Implications for therapy
por: Wang, QingQing, et al.
Publicado: (2018) -
DNA methylation in Friedreich ataxia silences expression of frataxin isoform E
por: Rodden, Layne N., et al.
Publicado: (2022)