Cargando…

Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington’s Disease

Huntington’s disease (HD) is a dominantly inherited neurodegenerative disease caused by an increase in CAG repeats in the Huntingtin gene (HTT). The striatum is one of the most vulnerable brain regions in HD, and altered delivery of BDNF to the striatum is believed to underlie this high vulnerabilit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Chenglong, Li, Chun Hei, Chen, Sidong, Yoo, Hanna, Qin, Xianan, Park, Hyokeun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242964/ https://www.ncbi.nlm.nih.gov/pubmed/30451892 http://dx.doi.org/10.1038/s41598-018-34883-w

Ejemplares similares

Altered Synaptic Vesicle Release and Ca(2+) Influx at Single Presynaptic Terminals of Cortical Neurons in a Knock-in Mouse Model of Huntington’s Disease
por: Chen, Sidong, et al.
Publicado: (2018)

Altered exocytosis of inhibitory synaptic vesicles at single presynaptic terminals of cultured striatal neurons in a knock-in mouse model of Huntington’s disease
por: Xu, Chen, et al.
Publicado: (2023)

Real-time three-dimensional tracking of single vesicles reveals abnormal motion and pools of synaptic vesicles in neurons of Huntington's disease mice
por: Chen, Sidong, et al.
Publicado: (2021)

Cortical Axonal Secretion of BDNF in the Striatum Is Disrupted in the Mutant-huntingtin Knock-in Mouse Model of Huntington's Disease
por: Park, Hyungju
Publicado: (2018)

Failure to Thrive: Impaired BDNF Transport along the Cortical–Striatal Axis in Mouse Q140 Neurons of Huntington’s Disease
por: Maloney, Michael T., et al.
Publicado: (2023)

Nurr1 Is Not an Essential Regulator of BDNF in Mouse Cortical Neurons
por: Abdollahi, Mona, et al.
Publicado: (2022)

Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction
por: Giralt, Albert, et al.
Publicado: (2011)

Abnormal Brain Development in Huntington’ Disease Is Recapitulated in the zQ175 Knock-In Mouse Model
por: Zhang, Chuangchuang, et al.
Publicado: (2020)

Conditioned taste aversion memory extinction temporally induces insular cortical BDNF release and inhibits neuronal apoptosis
por: Liu, Dian-Wei, et al.
Publicado: (2019)

PLD1 participates in BDNF-induced signalling in cortical neurons
por: Ammar, Mohamed Raafet, et al.
Publicado: (2015)

Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons From a Mouse Model of Huntington Disease
por: Smith-Dijak, Amy I., et al.
Publicado: (2019)

Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington’s Disease Knock-In Mouse Models
por: Franich, Nicholas R., et al.
Publicado: (2018)

The Utility of BDNF Detection in Assessing Severity of Huntington’s Disease
por: Plinta, Klaudia, et al.
Publicado: (2021)

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice
por: Beccano-Kelly, Dayne A., et al.
Publicado: (2014)

Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out
por: Loupe, Jacob M, et al.
Publicado: (2020)

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175
por: Menalled, Liliana B., et al.
Publicado: (2012)

Commentary on “Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice”
por: Popugaeva, Elena, et al.
Publicado: (2014)

Differential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease
por: Deng, Yun-Ping, et al.
Publicado: (2014)

Impaired TrkB Signaling Underlies Reduced BDNF-Mediated Trophic Support of Striatal Neurons in the R6/2 Mouse Model of Huntington’s Disease
por: Nguyen, Khanh Q., et al.
Publicado: (2016)

The presence of cortical neurons in striatal-cortical co-cultures alters the effects of dopamine and BDNF on medium spiny neuron dendritic development
por: Penrod, Rachel D., et al.
Publicado: (2015)

Genetic Knock-Down of Hdac3 Does Not Modify Disease-Related Phenotypes in a Mouse Model of Huntington's Disease
por: Moumné, Lara, et al.
Publicado: (2012)

Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease
por: Sathasivam, Kirupa, et al.
Publicado: (2010)

Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington’s disease
por: Landles, Christian, et al.
Publicado: (2012)

A novel intergenic enhancer that regulates Bdnf expression in developing cortical neurons
por: Brookes, Emily, et al.
Publicado: (2022)

Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington’s Disease Knock-In Mice
por: Neto, João Luís, et al.
Publicado: (2017)

No association between polymorphisms in the BDNF gene and age at onset in Huntington disease
por: Mai, Maren, et al.
Publicado: (2006)

Localization of BDNF mRNA with the Huntington's disease protein in rat brain
por: Ma, Bin, et al.
Publicado: (2010)

Functional analysis of brain derived neurotrophic factor (BDNF) in Huntington’s disease
por: Zhou, Zhike, et al.
Publicado: (2021)

Screening inducers of neuronal BDNF gene transcription using primary cortical cell cultures from BDNF-luciferase transgenic mice
por: Fukuchi, Mamoru, et al.
Publicado: (2019)

Distinct histological alterations of cortical interneuron types in mouse models of Huntington’s disease
por: Voelkl, Kerstin, et al.
Publicado: (2022)

Genetic Knock-Down of HDAC7 Does Not Ameliorate Disease Pathogenesis in the R6/2 Mouse Model of Huntington's Disease
por: Benn, Caroline L., et al.
Publicado: (2009)

Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease
por: Peng, Qi, et al.
Publicado: (2016)

Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington’s disease reveals early gray and white matter alterations
por: Pérot, Jean-Baptiste, et al.
Publicado: (2022)

Sulfasalazine decreases mouse cortical hyperexcitability
por: Alcoreza, Oscar, et al.
Publicado: (2019)

Cortical and Striatal Circuits in Huntington’s Disease
por: Blumenstock, Sonja, et al.
Publicado: (2020)

Systemic Delivery of Recombinant Brain Derived Neurotrophic Factor (BDNF) in the R6/2 Mouse Model of Huntington’s Disease
por: Giampà, Carmela, et al.
Publicado: (2013)

Modulation of Phospho-CREB by Systemically Administered Recombinant BDNF in the Hippocampus of the R6/2 Mouse Model of Huntington's Disease
por: Paldino, Emanuela, et al.
Publicado: (2019)

Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway
por: Bagayogo, Issa P, et al.
Publicado: (2009)

BDNF Expression in Cortical GABAergic Interneurons
por: Tomás, Federico José Barreda, et al.
Publicado: (2020)

Msh2 Acts in Medium-Spiny Striatal Neurons as an Enhancer of CAG Instability and Mutant Huntingtin Phenotypes in Huntington’s Disease Knock-In Mice
por: Kovalenko, Marina, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ttsbljanq19lb88vmhagi0r3d2