Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion

Immune challenge of invading macrophages at sites of infection is associated with release of TNF, which triggers a local cytokine storm as part of the normal inflammatory response. Whereas this response maybe beneficial in fighting off infections, similar responses triggered in autoimmune diseases c...

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Detalles Bibliográficos
Autores principales: Scarneo, Scott A., Mansourati, Antoine, Eibschutz, Liesl S., Totzke, Juliane, Roques, Jose R., Loiselle, David, Carlson, David, Hughes, Philip, Haystead, Timothy A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242965/
https://www.ncbi.nlm.nih.gov/pubmed/30451876
http://dx.doi.org/10.1038/s41598-018-35189-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242965/
https://www.ncbi.nlm.nih.gov/pubmed/30451876
http://dx.doi.org/10.1038/s41598-018-35189-7

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