N-myristoylation of Antimicrobial Peptide CM4 Enhances Its Anticancer Activity by Interacting With Cell Membrane and Targeting Mitochondria in Breast Cancer Cells

Development of antimicrobial peptides (AMPs) as highly effective and selective anticancer agents would represent great progress in cancer treatment. Here we show that myristoyl-CM4, a new synthetic analog generated by N-myristoylation of AMPs CM4, had anticancer activity against MCF-7, MDA-MB-231, M...

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Detalles Bibliográficos
Autores principales: Li, Caiyun, Liu, Hongyan, Yang, Yunqing, Xu, Xixi, Lv, Tongtong, Zhang, Huidan, Liu, Kehang, Zhang, Shuangquan, Chen, Yuqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242968/
https://www.ncbi.nlm.nih.gov/pubmed/30483133
http://dx.doi.org/10.3389/fphar.2018.01297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242968/
https://www.ncbi.nlm.nih.gov/pubmed/30483133
http://dx.doi.org/10.3389/fphar.2018.01297

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