Orthogonal Cas9–Cas9 chimeras provide a versatile platform for genome editing

The development of robust, versatile and accurate toolsets is critical to facilitate therapeutic genome editing applications. Here we establish RNA-programmable Cas9-Cas9 chimeras, in single- and dual-nuclease formats, as versatile genome engineering systems. In both of these formats, Cas9-Cas9 fusi...

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Detalles Bibliográficos
Autores principales: Bolukbasi, Mehmet Fatih, Liu, Pengpeng, Luk, Kevin, Kwok, Samantha F., Gupta, Ankit, Amrani, Nadia, Sontheimer, Erik J., Zhu, Lihua Julie, Wolfe, Scot A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242970/
https://www.ncbi.nlm.nih.gov/pubmed/30451839
http://dx.doi.org/10.1038/s41467-018-07310-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242970/
https://www.ncbi.nlm.nih.gov/pubmed/30451839
http://dx.doi.org/10.1038/s41467-018-07310-x

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