Cargando…
Enhanced inter-compartmental Ca(2+) flux modulates mitochondrial metabolism and apoptotic threshold during aging
BACKGROUND: Senescence is characterized by a gradual decline in cellular functions, including changes in energy homeostasis and decreased proliferation activity. As cellular power plants, contributors to signal transduction, sources of reactive oxygen species (ROS) and executors of programmed cell d...
Autores principales: | Madreiter-Sokolowski, Corina T., Waldeck-Weiermair, Markus, Bourguignon, Marie-Pierre, Villeneuve, Nicole, Gottschalk, Benjamin, Klec, Christiane, Stryeck, Sarah, Radulovic, Snjezana, Parichatikanond, Warisara, Frank, Saša, Madl, Tobias, Malli, Roland, Graier, Wolfgang F. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243020/ https://www.ncbi.nlm.nih.gov/pubmed/30458321 http://dx.doi.org/10.1016/j.redox.2018.11.003 |
Ejemplares similares
-
Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2+)
por: Waldeck-Weiermair, Markus, et al.
Publicado: (2015) -
Resveratrol Specifically Kills Cancer Cells by a Devastating Increase in the Ca(2+) Coupling Between the Greatly Tethered Endoplasmic Reticulum and Mitochondria
por: Madreiter-Sokolowski, Corina T., et al.
Publicado: (2016) -
PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells
por: Madreiter-Sokolowski, Corina T., et al.
Publicado: (2016) -
UCP2 modulates single-channel properties of a MCU-dependent Ca(2+) inward current in mitochondria
por: Bondarenko, Alexander I., et al.
Publicado: (2015) -
MICU1 controls cristae junction and spatially anchors mitochondrial Ca(2+) uniporter complex
por: Gottschalk, Benjamin, et al.
Publicado: (2019)