TRPM8 Activation via 3-Iodothyronamine Blunts VEGF-Induced Transactivation of TRPV1 in Human Uveal Melanoma Cells

In human uveal melanoma (UM), tumor enlargement is associated with increases in aqueous humor vascular endothelial growth factor-A (VEGF-A) content that induce neovascularization. 3-Iodothyronamine (3-T(1)AM), an endogenous thyroid hormone metabolite, activates TRP melastatin 8 (TRPM8), which blunts...

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Detalles Bibliográficos
Autores principales: Walcher, Lia, Budde, Clara, Böhm, Arina, Reinach, Peter S., Dhandapani, Priyavathi, Ljubojevic, Nina, Schweiger, Markus W., von der Waydbrink, Henriette, Reimers, Ilka, Köhrle, Josef, Mergler, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243059/
https://www.ncbi.nlm.nih.gov/pubmed/30483120
http://dx.doi.org/10.3389/fphar.2018.01234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243059/
https://www.ncbi.nlm.nih.gov/pubmed/30483120
http://dx.doi.org/10.3389/fphar.2018.01234

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