RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A

Mutations in the LRRK2 gene cause autosomal-dominant Parkinson’s disease (PD), and both LRRK2 as well as RAB7L1 have been implicated in increased susceptibility to idiopathic PD. RAB7L1 has been shown to increase membrane-association and kinase activity of LRRK2, and both seem to be mechanistically...

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Detalles Bibliográficos
Autores principales: Madero-Pérez, Jesús, Fernández, Belén, Lara Ordóñez, Antonio Jesús, Fdez, Elena, Lobbestael, Evy, Baekelandt, Veerle, Hilfiker, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243087/
https://www.ncbi.nlm.nih.gov/pubmed/30483055
http://dx.doi.org/10.3389/fnmol.2018.00417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243087/
https://www.ncbi.nlm.nih.gov/pubmed/30483055
http://dx.doi.org/10.3389/fnmol.2018.00417

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