The Hypervariable Loops of Free TCRs Sample Multiple Distinct Metastable Conformations in Solution

CD4(+) and CD8(+) αβ T cell antigen recognition is determined by the interaction between the TCR Complementarity Determining Region (CDR) loops and the peptide-presenting MHC complex. These T cells are known for their ability to recognize multiple pMHC complexes, and for a necessary promiscuity that...

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Detalles Bibliográficos
Autores principales: Crooks, James E., Boughter, Christopher T., Scott, L. Ridgway, Adams, Erin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243104/
https://www.ncbi.nlm.nih.gov/pubmed/30483515
http://dx.doi.org/10.3389/fmolb.2018.00095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243104/
https://www.ncbi.nlm.nih.gov/pubmed/30483515
http://dx.doi.org/10.3389/fmolb.2018.00095

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