Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory

Chimeric antigen receptor (CAR) T cells with a long-lived memory phenotype are correlated with durable, complete remissions in patients with leukemia. However, not all CAR T cell products form robust memory populations, and those that do can induce chronic B cell aplasia in patients. To address thes...

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Detalles Bibliográficos
Autores principales: Viaud, Sophie, Ma, Jennifer S. Y., Hardy, Ian R., Hampton, Eric N., Benish, Brent, Sherwood, Lance, Nunez, Vanessa, Ackerman, Christopher J., Khialeeva, Elvira, Weglarz, Meredith, Lee, Sung Chang, Woods, Ashley K., Young, Travis S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243241/
https://www.ncbi.nlm.nih.gov/pubmed/30373813
http://dx.doi.org/10.1073/pnas.1810060115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243241/
https://www.ncbi.nlm.nih.gov/pubmed/30373813
http://dx.doi.org/10.1073/pnas.1810060115

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