Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs

Immunomodulatory drugs (IMiDs), including thalidomide derivatives such as lenalidomide and pomalidomide, offer therapeutic benefit in several hematopoietic malignancies and autoimmune/inflammatory diseases. However, it is difficult to study the IMiD mechanism of action in murine disease models becau...

Descripción completa

Detalles Bibliográficos
Autores principales: Gemechu, Yohannes, Millrine, David, Hashimoto, Shigeru, Prakash, Jaya, Sanchenkova, Ksenia, Metwally, Hozaifa, Gyanu, Parajuli, Kang, Sujin, Kishimoto, Tadamitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243262/
https://www.ncbi.nlm.nih.gov/pubmed/30373817
http://dx.doi.org/10.1073/pnas.1814446115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243262/
https://www.ncbi.nlm.nih.gov/pubmed/30373817
http://dx.doi.org/10.1073/pnas.1814446115

Ejemplares similares