Modular Pore-Forming Immunotoxins with Caged Cytotoxicity Tailored by Directed Evolution

[Image: see text] Immunotoxins are proteins containing a cell-targeting element linked to a toxin that are under investigation for next-generation cancer treatment. However, these agents are difficult to synthesize, chemically heterogeneous, expensive, and show toxicity toward healthy cells. In this...

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Detalles Bibliográficos
Autores principales: Mutter, Natalie L., Soskine, Misha, Huang, Gang, Albuquerque, Inês S., Bernardes, Gonçalo J. L., Maglia, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243392/
https://www.ncbi.nlm.nih.gov/pubmed/30278129
http://dx.doi.org/10.1021/acschembio.8b00720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243392/
https://www.ncbi.nlm.nih.gov/pubmed/30278129
http://dx.doi.org/10.1021/acschembio.8b00720

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