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Modular Pore-Forming Immunotoxins with Caged Cytotoxicity Tailored by Directed Evolution
[Image: see text] Immunotoxins are proteins containing a cell-targeting element linked to a toxin that are under investigation for next-generation cancer treatment. However, these agents are difficult to synthesize, chemically heterogeneous, expensive, and show toxicity toward healthy cells. In this...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243392/ https://www.ncbi.nlm.nih.gov/pubmed/30278129 http://dx.doi.org/10.1021/acschembio.8b00720 |