Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma

[Image: see text] Even in the era of personalized medicine and immunotherapy, temozolomide (TMZ), a small molecule DNA alkylating agent, remains the standard-of-care for glioblastoma (GBM). TMZ has an unusual mode-of-action, spontaneously converting to its active component via hydrolysis in vivo. Wh...

Descripción completa

Detalles Bibliográficos
Autores principales: Svec, Riley L., Furiassi, Lucia, Skibinski, Christine G., Fan, Timothy M., Riggins, Gregory J., Hergenrother, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243397/
https://www.ncbi.nlm.nih.gov/pubmed/30296373
http://dx.doi.org/10.1021/acschembio.8b00864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243397/
https://www.ncbi.nlm.nih.gov/pubmed/30296373
http://dx.doi.org/10.1021/acschembio.8b00864

Ejemplares similares