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Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma

[Image: see text] Even in the era of personalized medicine and immunotherapy, temozolomide (TMZ), a small molecule DNA alkylating agent, remains the standard-of-care for glioblastoma (GBM). TMZ has an unusual mode-of-action, spontaneously converting to its active component via hydrolysis in vivo. Wh...

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Detalles Bibliográficos
Autores principales:	Svec, Riley L., Furiassi, Lucia, Skibinski, Christine G., Fan, Timothy M., Riggins, Gregory J., Hergenrother, Paul J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243397/ https://www.ncbi.nlm.nih.gov/pubmed/30296373 http://dx.doi.org/10.1021/acschembio.8b00864

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