Facile folding of insulin variants bearing a prosthetic C-peptide prepared by α-ketoacid-hydroxylamine (KAHA) ligation

The chemical synthesis of insulin is an enduring challenge due to the hydrophobic peptide chains and construction of the correct intermolecular disulfide pattern. We report a new approach to the chemical synthesis of insulin using a short, traceless, prosthetic C-peptide that facilitates the formati...

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Detalles Bibliográficos
Autores principales: Boross, Gábor N., Shimura, Satomi, Besenius, Melissa, Tennagels, Norbert, Rossen, Kai, Wagner, Michael, Bode, Jeffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243641/
https://www.ncbi.nlm.nih.gov/pubmed/30542587
http://dx.doi.org/10.1039/c8sc03738h