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Branched BBB-shuttle peptides: chemoselective modification of proteins to enhance blood–brain barrier transport
The blood–brain barrier (BBB) hampers the delivery of therapeutic proteins into the brain. BBB-shuttle peptides have been conjugated to therapeutic payloads to increase the permeability of these molecules. However, most BBB-shuttles have several limitations, such as a lack of resistance to proteases...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243681/ https://www.ncbi.nlm.nih.gov/pubmed/30542590 http://dx.doi.org/10.1039/c8sc02415d |