Identification of a new SYT2 variant validates an unusual distal motor neuropathy phenotype

OBJECTIVE: To report a new SYT2 missense mutation causing distal hereditary motor neuropathy and presynaptic neuromuscular junction (NMJ) transmission dysfunction. METHODS: We report a multigenerational family with a new missense mutation, c. 1112T>A (p. Ile371Lys), in the C2B domain of SYT2, des...

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Detalles Bibliográficos
Autores principales: Montes-Chinea, Nataly I., Guan, Zhuo, Coutts, Marcella, Vidal, Cecilia, Courel, Steve, Rebelo, Adriana P., Abreu, Lisa, Zuchner, Stephan, Littleton, J. Troy, Saporta, Mario A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244021/
https://www.ncbi.nlm.nih.gov/pubmed/30533528
http://dx.doi.org/10.1212/NXG.0000000000000282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244021/
https://www.ncbi.nlm.nih.gov/pubmed/30533528
http://dx.doi.org/10.1212/NXG.0000000000000282

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