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Synthesis of unnatural α-amino esters using ethyl nitroacetate and condensation or cycloaddition reactions
We report here on the use of ethyl nitroacetate as a glycine template to produce α-amino esters. This started with a study of its condensation with various arylacetals to give ethyl 3-aryl-2-nitroacrylates followed by a reduction (NaBH(4) and then zinc/HCl) into α-amino esters. The scope of this met...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244114/ https://www.ncbi.nlm.nih.gov/pubmed/30498535 http://dx.doi.org/10.3762/bjoc.14.263 |