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Synthesis of unnatural α-amino esters using ethyl nitroacetate and condensation or cycloaddition reactions

We report here on the use of ethyl nitroacetate as a glycine template to produce α-amino esters. This started with a study of its condensation with various arylacetals to give ethyl 3-aryl-2-nitroacrylates followed by a reduction (NaBH(4) and then zinc/HCl) into α-amino esters. The scope of this met...

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Detalles Bibliográficos
Autores principales:	Gagnot, Glwadys, Hervin, Vincent, Coutant, Eloi P, Desmons, Sarah, Baatallah, Racha, Monnot, Victor, Janin, Yves L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2018
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244114/ https://www.ncbi.nlm.nih.gov/pubmed/30498535 http://dx.doi.org/10.3762/bjoc.14.263

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