Activation Stoichiometry and Pore Architecture of TRPA1 Probed with Channel Concatemers

The nociceptor ion channel TRPA1 detects a wide range of hazardous chemicals, including reactive electrophiles such as cinnamaldehyde, which gate the channel allowing Na(+) and Ca(2+) entry. TRPA1 assembles as a tetramer, with a central pore within which an aspartate residue (D918) determines Ca(2+)...

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Detalles Bibliográficos
Autores principales: Ye, Wenlei, Tu, Yu-Hsiang, Cooper, Alexander J., Zhang, Zheng, Katritch, Vsevolod, Liman, Emily R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244152/
https://www.ncbi.nlm.nih.gov/pubmed/30459425
http://dx.doi.org/10.1038/s41598-018-35435-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244152/
https://www.ncbi.nlm.nih.gov/pubmed/30459425
http://dx.doi.org/10.1038/s41598-018-35435-y

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