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Activation Stoichiometry and Pore Architecture of TRPA1 Probed with Channel Concatemers
The nociceptor ion channel TRPA1 detects a wide range of hazardous chemicals, including reactive electrophiles such as cinnamaldehyde, which gate the channel allowing Na(+) and Ca(2+) entry. TRPA1 assembles as a tetramer, with a central pore within which an aspartate residue (D918) determines Ca(2+)...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244152/ https://www.ncbi.nlm.nih.gov/pubmed/30459425 http://dx.doi.org/10.1038/s41598-018-35435-y |