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Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells

Ataxin-1 mutation, arising from a polyglutamine (polyQ) tract expansion, is the underlying genetic cause of the late-onset neurodegenerative disease Spinocerebellar ataxia type 1 (SCA1). To identify protein partners of polyQ-ataxin-1 in neuronal cells under control or stress conditions, here we repo...

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Detalles Bibliográficos
Autores principales: Zhang, Sunyuan, Williamson, Nicholas A., Bogoyevitch, Marie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244183/
https://www.ncbi.nlm.nih.gov/pubmed/30457570
http://dx.doi.org/10.1038/sdata.2018.262