Using single nucleotide variations in single-cell RNA-seq to identify subpopulations and genotype-phenotype linkage

Despite its popularity, characterization of subpopulations with transcript abundance is subject to a significant amount of noise. We propose to use effective and expressed nucleotide variations (eeSNVs) from scRNA-seq as alternative features for tumor subpopulation identification. We develop a linea...

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Detalles Bibliográficos
Autores principales: Poirion, Olivier, Zhu, Xun, Ching, Travers, Garmire, Lana X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244222/
https://www.ncbi.nlm.nih.gov/pubmed/30459309
http://dx.doi.org/10.1038/s41467-018-07170-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244222/
https://www.ncbi.nlm.nih.gov/pubmed/30459309
http://dx.doi.org/10.1038/s41467-018-07170-5

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