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Using single nucleotide variations in single-cell RNA-seq to identify subpopulations and genotype-phenotype linkage
Despite its popularity, characterization of subpopulations with transcript abundance is subject to a significant amount of noise. We propose to use effective and expressed nucleotide variations (eeSNVs) from scRNA-seq as alternative features for tumor subpopulation identification. We develop a linea...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244222/ https://www.ncbi.nlm.nih.gov/pubmed/30459309 http://dx.doi.org/10.1038/s41467-018-07170-5 |