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Understanding the Thalidomide Chirality in Biological Processes by the Self-disproportionation of Enantiomers
Twenty years after the thalidomide disaster in the late 1950s, Blaschke et al. reported that only the (S)-enantiomer of thalidomide is teratogenic. However, other work has shown that the enantiomers of thalidomide interconvert in vivo, which begs the question: why is teratogen activity not observed...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244226/ https://www.ncbi.nlm.nih.gov/pubmed/30459439 http://dx.doi.org/10.1038/s41598-018-35457-6 |