p66Shc activation promotes increased oxidative phosphorylation and renders CNS cells more vulnerable to amyloid beta toxicity

A key pathological feature of Alzheimer’s disease (AD) is the accumulation of the neurotoxic amyloid beta (Aβ) peptide within the brains of affected individuals. Previous studies have shown that neuronal cells selected for resistance to Aβ toxicity display a metabolic shift from mitochondrial-depend...

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Detalles Bibliográficos
Autores principales: Lone, Asad, Harris, Richard A., Singh, Olivia, Betts, Dean H., Cumming, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244282/
https://www.ncbi.nlm.nih.gov/pubmed/30459314
http://dx.doi.org/10.1038/s41598-018-35114-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244282/
https://www.ncbi.nlm.nih.gov/pubmed/30459314
http://dx.doi.org/10.1038/s41598-018-35114-y

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