Affinity profiling of monoclonal antibody and antibody-drug-conjugate preparations by coupled liquid chromatography-surface plasmon resonance biosensing

Monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) are highly potent biopharmaceuticals designed for targeted cancer therapies. mAbs and ADCs can undergo modifications during production and storage which may affect binding to target receptors, potentially altering drug efficacy. In thi...

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Detalles Bibliográficos
Autores principales: Lakayan, Dina, Haselberg, Rob, Gahoual, Rabah, Somsen, Govert W., Kool, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Paper in Forefront
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244757/
https://www.ncbi.nlm.nih.gov/pubmed/30328504
http://dx.doi.org/10.1007/s00216-018-1414-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244757/
https://www.ncbi.nlm.nih.gov/pubmed/30328504
http://dx.doi.org/10.1007/s00216-018-1414-y

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