Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A(2A) Receptor Antagonist MSX-2

The compound L-valine-3-{8-[(E)-2-[3-methoxyphenyl)ethenyl]-7-methyl-1-propargyl­xan­thine-3-yl}propyl ester hydrochloride (MSX-4) was synthesized as an amino acid ester prodrug of the adenosine A(2A) receptor antagonist MSX-2. It was found to be stable in artificial gastric acid, but readily cleave...

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Detalles Bibliográficos
Autores principales: Vollmann, Karl, Qurishi, Ramatullah, Hockemeyer, Jörg, Müller, Christa E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244838/
https://www.ncbi.nlm.nih.gov/pubmed/18305423
http://dx.doi.org/10.3390/molecules13020348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244838/
https://www.ncbi.nlm.nih.gov/pubmed/18305423
http://dx.doi.org/10.3390/molecules13020348

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