Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A(2A) Receptor Antagonist MSX-2

The compound L-valine-3-{8-[(E)-2-[3-methoxyphenyl)ethenyl]-7-methyl-1-propargyl­xan­thine-3-yl}propyl ester hydrochloride (MSX-4) was synthesized as an amino acid ester prodrug of the adenosine A(2A) receptor antagonist MSX-2. It was found to be stable in artificial gastric acid, but readily cleave...

Descripción completa

Detalles Bibliográficos
Autores principales: Vollmann, Karl, Qurishi, Ramatullah, Hockemeyer, Jörg, Müller, Christa E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244838/
https://www.ncbi.nlm.nih.gov/pubmed/18305423
http://dx.doi.org/10.3390/molecules13020348
_version_ 1783372125094019072
author Vollmann, Karl
Qurishi, Ramatullah
Hockemeyer, Jörg
Müller, Christa E.
author_facet Vollmann, Karl
Qurishi, Ramatullah
Hockemeyer, Jörg
Müller, Christa E.
author_sort Vollmann, Karl
collection PubMed
description The compound L-valine-3-{8-[(E)-2-[3-methoxyphenyl)ethenyl]-7-methyl-1-propargyl­xan­thine-3-yl}propyl ester hydrochloride (MSX-4) was synthesized as an amino acid ester prodrug of the adenosine A(2A) receptor antagonist MSX-2. It was found to be stable in artificial gastric acid, but readily cleaved by pig liver esterase.
format Online
Article
Text
id pubmed-6244838
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62448382018-11-26 Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A(2A) Receptor Antagonist MSX-2 Vollmann, Karl Qurishi, Ramatullah Hockemeyer, Jörg Müller, Christa E. Molecules Article The compound L-valine-3-{8-[(E)-2-[3-methoxyphenyl)ethenyl]-7-methyl-1-propargyl­xan­thine-3-yl}propyl ester hydrochloride (MSX-4) was synthesized as an amino acid ester prodrug of the adenosine A(2A) receptor antagonist MSX-2. It was found to be stable in artificial gastric acid, but readily cleaved by pig liver esterase. MDPI 2008-02-12 /pmc/articles/PMC6244838/ /pubmed/18305423 http://dx.doi.org/10.3390/molecules13020348 Text en © 2008 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Vollmann, Karl
Qurishi, Ramatullah
Hockemeyer, Jörg
Müller, Christa E.
Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A(2A) Receptor Antagonist MSX-2
title Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A(2A) Receptor Antagonist MSX-2
title_full Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A(2A) Receptor Antagonist MSX-2
title_fullStr Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A(2A) Receptor Antagonist MSX-2
title_full_unstemmed Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A(2A) Receptor Antagonist MSX-2
title_short Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A(2A) Receptor Antagonist MSX-2
title_sort synthesis and properties of a new water-soluble prodrug of the adenosine a(2a) receptor antagonist msx-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244838/
https://www.ncbi.nlm.nih.gov/pubmed/18305423
http://dx.doi.org/10.3390/molecules13020348
work_keys_str_mv AT vollmannkarl synthesisandpropertiesofanewwatersolubleprodrugoftheadenosinea2areceptorantagonistmsx2
AT qurishiramatullah synthesisandpropertiesofanewwatersolubleprodrugoftheadenosinea2areceptorantagonistmsx2
AT hockemeyerjorg synthesisandpropertiesofanewwatersolubleprodrugoftheadenosinea2areceptorantagonistmsx2
AT mullerchristae synthesisandpropertiesofanewwatersolubleprodrugoftheadenosinea2areceptorantagonistmsx2

Ejemplares similares