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Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A(2A) Receptor Antagonist MSX-2

The compound L-valine-3-{8-[(E)-2-[3-methoxyphenyl)ethenyl]-7-methyl-1-propargylxanthine-3-yl}propyl ester hydrochloride (MSX-4) was synthesized as an amino acid ester prodrug of the adenosine A(2A) receptor antagonist MSX-2. It was found to be stable in artificial gastric acid, but readily cleave...

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Detalles Bibliográficos
Autores principales:	Vollmann, Karl, Qurishi, Ramatullah, Hockemeyer, Jörg, Müller, Christa E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244838/ https://www.ncbi.nlm.nih.gov/pubmed/18305423 http://dx.doi.org/10.3390/molecules13020348

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