Enhanced Absorption and Growth Inhibition with Amino Acid Monoester Prodrugs of Floxuridine by Targeting hPEPT1 Transporters

A series of amino acid monoester prodrugs of floxuridine was synthesized and evaluated for the improvement of oral bioavailability and the feasibility of target drug delivery via oligopeptide transporters. All floxuridine 5′-amino acid monoester prodrugs exhibited PEPT1 affinity, with inhibition coe...

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Detalles Bibliográficos
Autores principales: Tsume, Yasuhiro, Vig, Balvinder S., Sun, Jing, Landowski, Christopher P., Hilfinger, John M., Ramachandran, Chandrasekharan, Amidon, Gordon L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244841/
https://www.ncbi.nlm.nih.gov/pubmed/18719516
http://dx.doi.org/10.3390/molecules13071441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244841/
https://www.ncbi.nlm.nih.gov/pubmed/18719516
http://dx.doi.org/10.3390/molecules13071441

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