Translational PK-PD modeling analysis of MCLA-128, a HER2/HER3 bispecific monoclonal antibody, to predict clinical efficacious exposure and dose

Introduction MCLA-128 is a bispecific monoclonal antibody targeting the HER2 and HER3 receptors. Pharmacokinetics (PK) and pharmacodynamics (PD) of MCLA-128 have been evaluated in preclinical studies in cynomolgus monkeys and mice. The aim of this study was to characterize the PK and PD of MCLA-128...

Descripción completa

Detalles Bibliográficos
Autores principales: de Vries Schultink, Aurelia H. M., Doornbos, Robert P., Bakker, Alexander B. H., Bol, Kees, Throsby, Mark, Geuijen, Cecile, Maussang, David, Schellens, Jan H. M., Beijnen, Jos H., Huitema, Alwin D. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Preclinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244972/
https://www.ncbi.nlm.nih.gov/pubmed/29728897
http://dx.doi.org/10.1007/s10637-018-0593-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244972/
https://www.ncbi.nlm.nih.gov/pubmed/29728897
http://dx.doi.org/10.1007/s10637-018-0593-x

Ejemplares similares