Effects of Anonaine on Dopamine Biosynthesis and l-DOPA-Induced Cytotoxicity in PC12 Cells

The effects of anonaine, an aporphine isoquinoline alkaloid, on dopamine biosynthesis and l-DOPA-induced cytotoxicity in PC12 cells were investigated. Anonaine at concentration ranges of 0.01-0.2 μM showed a significant inhibition of dopamine content at 24 h, with an IC(50) value of 0.05 μM. Anonain...

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Detalles Bibliográficos
Autores principales: Lee, Jae Joon, Jin, Chun Mei, Kim, Young Kyoon, Ryu, Shi Yong, Lim, Sung Cil, Lee, Myung Koo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Full Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245076/
https://www.ncbi.nlm.nih.gov/pubmed/18305432
http://dx.doi.org/10.3390/molecules13020475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245076/
https://www.ncbi.nlm.nih.gov/pubmed/18305432
http://dx.doi.org/10.3390/molecules13020475

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