Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1

The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been made accessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclic benzofuranones 2 and 3, respectively. A four-step synthesis to spirocompound 4 is described. The novel spirocyclic benzofuranones...

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Detalles Bibliográficos
Autores principales: Braun, Manfred, Hessamian-Alinejad, Anahita, de Lacroix, Boris Féaux, Alvarez, Birte Hernandez, Fischer, Gunter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245329/
https://www.ncbi.nlm.nih.gov/pubmed/18463601
http://dx.doi.org/10.3390/molecules13040995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245329/
https://www.ncbi.nlm.nih.gov/pubmed/18463601
http://dx.doi.org/10.3390/molecules13040995

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