Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1

The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been made accessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclic benzofuranones 2 and 3, respectively. A four-step synthesis to spirocompound 4 is described. The novel spirocyclic benzofuranones...

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Autores principales: Braun, Manfred, Hessamian-Alinejad, Anahita, de Lacroix, Boris Féaux, Alvarez, Birte Hernandez, Fischer, Gunter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245329/
https://www.ncbi.nlm.nih.gov/pubmed/18463601
http://dx.doi.org/10.3390/molecules13040995
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author Braun, Manfred
Hessamian-Alinejad, Anahita
de Lacroix, Boris Féaux
Alvarez, Birte Hernandez
Fischer, Gunter
author_facet Braun, Manfred
Hessamian-Alinejad, Anahita
de Lacroix, Boris Féaux
Alvarez, Birte Hernandez
Fischer, Gunter
author_sort Braun, Manfred
collection PubMed
description The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been made accessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclic benzofuranones 2 and 3, respectively. A four-step synthesis to spirocompound 4 is described. The novel spirocyclic benzofuranones display modest to no inhibition of the human peptidyl prolyl cis/trans isomerase Pin1.
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spelling pubmed-62453292018-11-26 Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1 Braun, Manfred Hessamian-Alinejad, Anahita de Lacroix, Boris Féaux Alvarez, Birte Hernandez Fischer, Gunter Molecules Article The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been made accessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclic benzofuranones 2 and 3, respectively. A four-step synthesis to spirocompound 4 is described. The novel spirocyclic benzofuranones display modest to no inhibition of the human peptidyl prolyl cis/trans isomerase Pin1. MDPI 2008-04-29 /pmc/articles/PMC6245329/ /pubmed/18463601 http://dx.doi.org/10.3390/molecules13040995 Text en © 2008 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Braun, Manfred
Hessamian-Alinejad, Anahita
de Lacroix, Boris Féaux
Alvarez, Birte Hernandez
Fischer, Gunter
Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1
title Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1
title_full Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1
title_fullStr Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1
title_full_unstemmed Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1
title_short Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1
title_sort novel spiroannulated 3-benzofuranones. synthesis and inhibition of the human peptidyl prolyl cis/trans isomerase pin1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245329/
https://www.ncbi.nlm.nih.gov/pubmed/18463601
http://dx.doi.org/10.3390/molecules13040995
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