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Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine(†)

Strictosidine, the precursor of more than 2,500 indole alkaloids, was isolated from four species of three plant families. By searching the Dictionary of Natural Products on DVD it was found that about 150 indole alkaloids were obtained from the same species (coalkaloids), which is a direct proof of...

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Autor principal: Szabó, László F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245392/
https://www.ncbi.nlm.nih.gov/pubmed/18794791
http://dx.doi.org/10.3390/molecules13081875
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author Szabó, László F.
author_facet Szabó, László F.
author_sort Szabó, László F.
collection PubMed
description Strictosidine, the precursor of more than 2,500 indole alkaloids, was isolated from four species of three plant families. By searching the Dictionary of Natural Products on DVD it was found that about 150 indole alkaloids were obtained from the same species (coalkaloids), which is a direct proof of their common origin. On the base of their three-dimensional structure, taxonomic properties and standard reaction mechanisms an extended network was established which involved the four fundamental skeletons, the three types of carbon framework in the secologanin subunit and all major groups of indole alkaloids derived from secologanin and tryptamine (except a few minor groups, in which only less then 10 alkaloids were known). The system was extended to the heterodimer indole alkaloids and the quinoindole alkaloids as well.
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spelling pubmed-62453922018-11-26 Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine(†) Szabó, László F. Molecules Review Strictosidine, the precursor of more than 2,500 indole alkaloids, was isolated from four species of three plant families. By searching the Dictionary of Natural Products on DVD it was found that about 150 indole alkaloids were obtained from the same species (coalkaloids), which is a direct proof of their common origin. On the base of their three-dimensional structure, taxonomic properties and standard reaction mechanisms an extended network was established which involved the four fundamental skeletons, the three types of carbon framework in the secologanin subunit and all major groups of indole alkaloids derived from secologanin and tryptamine (except a few minor groups, in which only less then 10 alkaloids were known). The system was extended to the heterodimer indole alkaloids and the quinoindole alkaloids as well. MDPI 2008-08-27 /pmc/articles/PMC6245392/ /pubmed/18794791 http://dx.doi.org/10.3390/molecules13081875 Text en © 2008 by the authors. Licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Szabó, László F.
Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine(†)
title Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine(†)
title_full Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine(†)
title_fullStr Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine(†)
title_full_unstemmed Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine(†)
title_short Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine(†)
title_sort rigorous biogenetic network for a group of indole alkaloids derived from strictosidine(†)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245392/
https://www.ncbi.nlm.nih.gov/pubmed/18794791
http://dx.doi.org/10.3390/molecules13081875
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