Discovery of a Novel CCR5 Antagonist Lead Compound Through Fragment Assembly

CCR5, as the major co-receptor for HIV-1 entry, is an attractive novel target for the pharmaceutical industry in the HIV-1 therapeutic area. In this study, based on the structures of maraviroc and 1,4-bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)butane-1,4- dione (1), which was identified using struc...

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Detalles Bibliográficos
Autores principales: Liu, Yanqing, Zhou, Enkun, Yu, Kunqian, Zhu, Jin, Zhang, Yu, Xie, Xin, Li, Jian, Jiang, Hualiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245477/
https://www.ncbi.nlm.nih.gov/pubmed/18830165
http://dx.doi.org/10.3390/molecules13102426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245477/
https://www.ncbi.nlm.nih.gov/pubmed/18830165
http://dx.doi.org/10.3390/molecules13102426

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