Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents

A series of novel N-benzylidenesulfonohydrazide compounds were designed and synthesized as inhibitors of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) and UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD) from E. coli, involved in the biosynthesis of bacterial cell-walls. Some compounds po...

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Detalles Bibliográficos
Autores principales: Frlan, Rok, Kovač, Andreja, Blanot, Didier, Gobec, Stanislav, Pečar, Slavko, Obreza, Aleš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Full Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245483/
https://www.ncbi.nlm.nih.gov/pubmed/18259126
http://dx.doi.org/10.3390/molecules13010011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245483/
https://www.ncbi.nlm.nih.gov/pubmed/18259126
http://dx.doi.org/10.3390/molecules13010011

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