Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents

A series of novel N-benzylidenesulfonohydrazide compounds were designed and synthesized as inhibitors of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) and UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD) from E. coli, involved in the biosynthesis of bacterial cell-walls. Some compounds po...

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Detalles Bibliográficos
Autores principales: Frlan, Rok, Kovač, Andreja, Blanot, Didier, Gobec, Stanislav, Pečar, Slavko, Obreza, Aleš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2008
Materias:
Full Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245483/
https://www.ncbi.nlm.nih.gov/pubmed/18259126
http://dx.doi.org/10.3390/molecules13010011
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author Frlan, Rok
Kovač, Andreja
Blanot, Didier
Gobec, Stanislav
Pečar, Slavko
Obreza, Aleš
author_facet Frlan, Rok
Kovač, Andreja
Blanot, Didier
Gobec, Stanislav
Pečar, Slavko
Obreza, Aleš
author_sort Frlan, Rok
collection PubMed
description A series of novel N-benzylidenesulfonohydrazide compounds were designed and synthesized as inhibitors of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) and UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD) from E. coli, involved in the biosynthesis of bacterial cell-walls. Some compounds possessed inhibitory activity against both enzymes with IC(50) values as low as 30 μM. In addition, a new, one-pot synthesis of amidobenzaldehydes is reported.
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spelling pubmed-62454832018-11-26 Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents Frlan, Rok Kovač, Andreja Blanot, Didier Gobec, Stanislav Pečar, Slavko Obreza, Aleš Molecules Full Paper A series of novel N-benzylidenesulfonohydrazide compounds were designed and synthesized as inhibitors of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) and UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD) from E. coli, involved in the biosynthesis of bacterial cell-walls. Some compounds possessed inhibitory activity against both enzymes with IC(50) values as low as 30 μM. In addition, a new, one-pot synthesis of amidobenzaldehydes is reported. MDPI 2008-01-11 /pmc/articles/PMC6245483/ /pubmed/18259126 http://dx.doi.org/10.3390/molecules13010011 Text en © 2008 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Full Paper
Frlan, Rok
Kovač, Andreja
Blanot, Didier
Gobec, Stanislav
Pečar, Slavko
Obreza, Aleš
Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents
title Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents
title_full Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents
title_fullStr Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents
title_full_unstemmed Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents
title_short Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents
title_sort design and synthesis of novel n-benzylidenesulfonohydrazide inhibitors of murc and murd as potential antibacterial agents
topic Full Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245483/
https://www.ncbi.nlm.nih.gov/pubmed/18259126
http://dx.doi.org/10.3390/molecules13010011
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