Species-Specific Transcriptional Regulation of Genes Involved in Nitric Oxide Production and Arginine Metabolism in Macrophages

Activated mouse macrophages metabolize arginine via NO synthase (NOS2) to produce NO as an antimicrobial effector. Published gene expression datasets provide little support for the activation of this pathway in human macrophages. Generation of NO requires the coordinated regulation of multiple genes...

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Detalles Bibliográficos
Autores principales: Young, Rachel, Bush, Stephen J., Lefevre, Lucas, McCulloch, Mary E. B., Lisowski, Zofia M., Muriuki, Charity, Waddell, Lindsey A., Sauter, Kristin A., Pridans, Clare, Clark, Emily L., Hume, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245571/
https://www.ncbi.nlm.nih.gov/pubmed/30467554
http://dx.doi.org/10.4049/immunohorizons.1700073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245571/
https://www.ncbi.nlm.nih.gov/pubmed/30467554
http://dx.doi.org/10.4049/immunohorizons.1700073

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