Structure of paused transcription complex Pol II-DSIF-NELF

Metazoan gene regulation often involves pausing of RNA polymerase II (Pol II) in the promoter-proximal region. Paused Pol II is stabilized by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation factor (NELF). Here we report the cryo-electron microscopy (cryo-EM) stru...

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Detalles Bibliográficos
Autores principales: Vos, Seychelle M., Farnung, Lucas, Urlaub, Henning, Cramer, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245578/
https://www.ncbi.nlm.nih.gov/pubmed/30135580
http://dx.doi.org/10.1038/s41586-018-0442-2