Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues

Fatty acid synthase (FASN) predominantly generates straight-chain fatty acids using acetyl-CoA as the initiating substrate. However, monomethyl branched-chain fatty acids (mmBCFAs) are also present in mammals but thought to be primarily diet-derived. Here we demonstrate that mmBCFAs are de novo synt...

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Detalles Bibliográficos
Autores principales: Wallace, Martina, Green, Courtney R., Roberts, Lindsay S., Lee, Yujung Michelle, McCarville, Justin L., Sanchez-Gurmaches, Joan, Meurs, Noah, Gengatharan, Jivani M., Hover, Justin D., Phillips, Susan A., Ciaraldi, Theodore P., Guertin, David A., Cabrales, Pedro, Ayres, Janelle S., Nomura, Daniel K., Loomba, Rohit, Metallo, Christian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245668/
https://www.ncbi.nlm.nih.gov/pubmed/30327559
http://dx.doi.org/10.1038/s41589-018-0132-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245668/
https://www.ncbi.nlm.nih.gov/pubmed/30327559
http://dx.doi.org/10.1038/s41589-018-0132-2

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