Highly sensitive detection of ALK resistance mutations in plasma using droplet digital PCR

BACKGROUND: On-target resistance mechanisms found in one-third of patients receiving anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are secondary ALK mutations in ALK-rearranged non-small cell lung cancer (NSCLC). There are large variations in the resistant mutations, unlike the...

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Detalles Bibliográficos
Autores principales: Yoshida, Ryohei, Sasaki, Takaaki, Umekage, Yasuhiro, Tanno, Sachie, Ono, Yusuke, Ogata, Munehiko, Chiba, Shinichi, Mizukami, Yusuke, Ohsaki, Yoshinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245722/
https://www.ncbi.nlm.nih.gov/pubmed/30453899
http://dx.doi.org/10.1186/s12885-018-5031-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245722/
https://www.ncbi.nlm.nih.gov/pubmed/30453899
http://dx.doi.org/10.1186/s12885-018-5031-0

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